Download e-book for kindle: ADP-Ribosylation: Metabolic Effects and Regulatory Functions by Takashi Sugimura, Masanao Miwa (auth.), Joel Moss, Peter

By Takashi Sugimura, Masanao Miwa (auth.), Joel Moss, Peter Zahradka (eds.)

ISBN-10: 1461361206

ISBN-13: 9781461361206

ISBN-10: 1461526140

ISBN-13: 9781461526148

Considering the present curiosity in mobile rules and intracellular signalling structures, it really is brilliant that the contribution of ADP-ribosylation reactions to the modulation of numerous particular telephone procedures, in parallel with different post-translational ameliorations equivalent to phosphorylation, has now not been often famous. whereas it isn't possible to hide all features of ADP-ribosylation, the thirty-one articles contained during this quantity offer a worthy assessment of contemporary growth within the box in the context of mobile keep watch over mechanisms. For the ease of the reader, many of the issues were grouped into numerous sections: (a) poly(ADP-ribosyl)ation; (b) mono-ADP-ribosylation; (c) toxin mono-ADP-ribosylation; (d) inhibitors and activators; (e) protein amendment with ADP-ribose and its analogues; and (f) non-modification kinds of ADP-ribose. The contents of the person chapters mirror the tips of the members, lots of whom have spent their careers trying to unravel the organic services of ADP-ribosylation. we are hoping that this e-book will function an invaluable reference for these investigators which are new to the world in addition to people who are actively learning ADP-ribosylation.

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Extra resources for ADP-Ribosylation: Metabolic Effects and Regulatory Functions

Sample text

A" ER" .. " " "Q" " " " .... + * 1 MAESSDKLYRVEYAKSGRAS LlSKNKD LlSRNKD G A APT PIS P P A A P ASVAATPPPSTASA~AAVNSSASADKPLSN~~LTLG Topo II PARP PARP PARP Orosophlla Xenopus Human V~P T I P~ I S P PLY Nl:J K F S~ I + + • * LlK NO H K LGGKAAGS ~L GGK FE V K * * ~KAMIEKLGGK~TGT VIKTLIE LlR KrnR E Lis DO A R FII IL E K C E K K L V V E N K 0 L K K YD T V L DI L R D L F Fig. 4. Alignments ofthe leucine zipper region of the transcription factors, human and Drosophila DNA topoisomerase II, and PARPs from human, Xenopus, and Drosophila.

Gradwohl G, Menissier-de Murcia J, Molinete M, Simonin F, Koken M, Hoeijmakers JH, and de Murcia G: The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA. Proc Natl Acad Sci USA 87: 2990--2994, 1990 32 26. Ikejima M, Noguchi S, Yamashita R, Ogura T, Sugimura T, Gill DM, Miwa M: The zinc fingers of human poly(ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation: Other structures recognize intact DNA.

Eur 1 Biochem 139: 81--86, 1984 3. Burtscher HI, Auer B, Klocker H, Schweiger M, Hirsch-Kauffman, M: Isolation of ADP-ribosyltransferase by affinity chromatography. Anal Biochem 152: 285--290, 1986 4. Ushiro H, Yokoyama Y, Shizuta, Y: Purification and characterization ofpoly(ADP-ribose) polymerase from human placenta. 1 Bioi Chern 262: 2352--2357, 1987 5. Mandel P, Okazaki H, Niedergang, C: Purification and properties of calfthymus polyadenosine diphosphate ribose polymerase, FEBS Lett 84: 331--336, 1977 6.

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ADP-Ribosylation: Metabolic Effects and Regulatory Functions by Takashi Sugimura, Masanao Miwa (auth.), Joel Moss, Peter Zahradka (eds.)


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