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By Luigi Amaducci, Marzia Baldereschi (auth.), Robert E. Becker, Ezio Giacobini, Joyce M. Barton, Mona Brown (eds.)

ISBN-10: 1461241162

ISBN-13: 9781461241164

ISBN-10: 1461286603

ISBN-13: 9781461286608

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Additional info for Alzheimer Disease: From Molecular Biology to Theraphy

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Differences in prevalence of NIDDM according to regions and races are well-known. , 1986) and 20% at the age of 80 (Morley and Perry, 1991). , 1993). Year Author n of Patients with Dementia Percentage of Diabetes AD(') Vascular Dementia 1983 Bucht et al. 5% 1988 Wolf-Klein et al. 7% 1992 Small et al. 9% 1993 Lanvin et al. 0% 1993 Mortel et al. 0% 1996 Nielson et al. 8% TABLE I: Frequency of diabetes according to the etiology of dementia dementia of Alzheimer type. (0) AD: 38 J-P. Michel et al. Yet, there has been little research on the interaction between these two diseases.

Neurosci Letts 103:234-239. McGeer PL, Walker DG, Akiyama H, Yasuhara 0 and McGeer EG (1994): Involvement of microglia in Alzheimer's disease. Neuropath Appl Neurobiol 20:191-192. Rogers J (1992): Anti-inflammatory agents as a therapeutic approach to Alzheimer's disease. Neurology 42:447-449. Rumble B, Retallack R, Hilbich C, Simms G, Multhaup G, Martins R, Hockey A, Montgomery P, Beyreuther K, Masters CL (1989): Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease. N Engl J Med 320:14461452.

The positive findings are the senile plaques, the neurofibrillary tangles, activated microglia and the neuropil threads; while the negative findings are loss of neurons and of synapses (Table 1). , 1964). Fibrous astrocytes are prominent on the periphery, while microglia hold a close relationship to the amyloid and are scattered in the neuropil. The tangles are found principally within the large and medium neurons of the hippocampal formation and entorhinal area, and in the neocortex. , 1985). Neuropil threads contain PHF and neurofilaments (Kowall and Kosik, 1987).

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Alzheimer Disease: From Molecular Biology to Theraphy by Luigi Amaducci, Marzia Baldereschi (auth.), Robert E. Becker, Ezio Giacobini, Joyce M. Barton, Mona Brown (eds.)

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