Download e-book for kindle: Antimetabolites in Biochemistry, Biology and Medicine. by J. Skoda, Peter Langen

By J. Skoda, Peter Langen

ISBN-10: 0080243843

ISBN-13: 9780080243849

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Read Online or Download Antimetabolites in Biochemistry, Biology and Medicine. Proceedings of a Symposium on Antimetabolites in Biochemistry, Biology and Medicine, Held in Prague, Czechoslovakia, July 10–12, 1978 PDF

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Extra resources for Antimetabolites in Biochemistry, Biology and Medicine. Proceedings of a Symposium on Antimetabolites in Biochemistry, Biology and Medicine, Held in Prague, Czechoslovakia, July 10–12, 1978

Sample text

The time dependent loss in enzyme activity which is recoverable upon gel filtration may be explained by a number of unproven rationalizations. , thiol ester), or a very potent reversible inhibitor may be produced by action of the enzyme on CF3dUMP. Further experiments are in progress to elucidate the exact mechanism of CF3dUMP with dTMP synthetase. As previously mentioned, the reactivity of such C-F bonds may be retained by vinylogous conjugation. In collaboration with Dr. Donald Bergstrom, we have found that 5-CF3CH=CH-dUrd is only slightly less susceptible to hydrolysis to the corresponding carboxylic acid than CF dUrd.

Sorm, Nucleic acid components and their analogues. LXV1. Hydrolysis of 5-azacytidine and its connection with biological activity. Collection Czech. Chem. 30, 2801 (1965). P. Brent, Periodicity of DNA synthetic enzymes durincr Hela cell cycle. Cell Tissue Kinet. 4, 297 (1971). 41 INHIBITORS OF THYMIDYLATE SYNTHETASE Daniel V. A. ABSTRACT Inhibition of thymidylate synthetase by 5-substituted-2'-deoxyuridylates has permitted quantitative structure-activity relationships to be established. From this, it was concluded that electron withdrawing 5-substituents enhance binding whereas bulky substituents are detrimental to binding.

179, 272 (1977). S. Shin, M. A. Williams, and E. L. R. Stokstad, Identification of folic acid compounds in rat liver, Biochem. Biophys. Res. Commun. 47, 35 (1972). M. Houlihan, and J. M, Scott, The identification of pteroylglutamates as the major folate derivatives in rat liver and the demonstration of its biosynthesis from exogenous [*%]pteroylglutamate, Biochem. Biophys. Res. Commun. 48, 1675 (1972). M. Baugh, E. Brawerman, and M. G. Nair, The identification of poly-γ-glutamyl chain lengths in bacterial folates, Biochemistry, 13, 4952 (1974).

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Antimetabolites in Biochemistry, Biology and Medicine. Proceedings of a Symposium on Antimetabolites in Biochemistry, Biology and Medicine, Held in Prague, Czechoslovakia, July 10–12, 1978 by J. Skoda, Peter Langen


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